Diagnostic Utility of CSF Tau and A𝜷_𝟒𝟐 in Dementia: A Meta-Analysis

Table 1

Effect size, its 95% CI, and % weight calculations for each selected study of CSF tau in Alzheimer’s disease and dementia due to other causes.

S. no.	Author’s name and year	Country where the studies were conducted	Tau level (pg/mL) (AD and control)						Effect size (pg/mL)		95% CI	Weight	Tau level (pg/mL) (DOC and control)						Effect size (pg/mL)		95% CI	Weight
			Diseased			Control							Diseased			Control
			N	Md^∗	SD	N	Mc^∗∗	SD	RMD^+	SE			N	Md^∗	SD	N	Mc^∗∗	SD	RMD^+	SE
1	Arai et al. (1995) [15]	Japan	19	919	349	19	9	4.5	910.00	80.07	753.06–1066.94	0.005	7	77.2	45.5	19	9	4.5	68.20	17.23	34.43–101.97	0.215
2	Tapiola et al. (1998) [16]	Finland	81	524	351	33	293	140	231.00	45.99	140.86–321.14	0.015	40	403	248	33	293	140	110.00	46.17	19.51–200.49	0.030
3	Galasko et al. (1998) [17]	USA	82	663	481	60	387	167	276.00	57.33	163.64–388.36	0.010	74	456	383	60	387	167	69.00	49.47	−27.96–165.96	0.026
4	Andreasen et al. (1998) [18]	Sweden	43	796	382	18	190	57	606.00	59.78	488.83–723.17	0.009	21	708	382	18	190	57	518.00	84.44	352.51–683.49	0.009
5	Kanai et al. (1998) [19]	Japan	32	489	297.5	41	217	128	272.00	56.26	161.73–382.27	0.010	33	267	146	41	217	128	50.00	32.34	−13.38–113.38	0.061
6	Andreasen et al. (2001) [7]	Sweden	105	759	417	18	264	102	495.00	47.27	402.36–587.64	0.014	23	461	280	18	264	102	197.00	63.14	73.25–320.75	0.016
7	Sjögren et al. (2002) [20]	Sweden	19	919	349	17	342	116	577.00	84.87	410.67–743.33	0.004	15	306	65	17	342	116	−36.00	32.76	−100.21–28.21	0.059
8	Grossman et al. (2005) [21]	US	17	534.6	303.5	13	260.4	93.8	274.20	78.07	121.18–427.22	0.005	73	207.1	270.3	13	260.4	93.8	−53.30	40.95	−133.58–26.98	0.038
9	de Jong et al. (2006) [22]	The Netherlands	61	613	326	30	184	89	429.00	44.79	341.21–516.79	0.016	50	303	307	30	184	89	119.00	46.36	28.14–209.86	0.030
10	Bibl et al. (2007) [23]	Germany	15	700	480	15	200	130	500.00	128.40	248.34–751.66	0.002	15	340	280	15	200	130	140.00	79.71	−16.22–296.22	0.010
11	Ravaglia et al. (2008) [24]	Italy	31	56.3	32.7	36	24.28	5.9	32.02	5.96	20.35–43.69	0.909	13	63.5	40.3	36	24.28	5.9	39.22	11.22	17.23–61.21	0.506

*Mean in diseased group, **Mean in control group and raw mean difference.