Diagnostic Utility of CSF Tau and A𝜷_𝟒𝟐 in Dementia: A Meta-Analysis

Table 6

Pooled estimate of effect size with 95% CI, test of significance, and magnitude of heterogeneity of CSF A𝛽₄₂ studies in Alzheimer’s disease and dementia due to other causes.

Statistics	Alzheimer’s disease	Dementia due to other causes
Pooled estimate of CSF Aβ 42 (pg/mL)	−363.926	−170.743
95% CI of pooled estimate (pg/mL)	−542.007–−185.845	−256.912–−84.574
Between-studies variance (𝑇^2)	54859.742	9755.39
Degree of heterogeneity (𝐼^2)	97.8%	83.7%
95% CI of 𝐼^2	96.8%–98.5%	69.7%–91.7%
Q statistics	271.051	36.780
DF	6	6
𝑃 value	0.000	0.000