Alzheimer's Disease Genes Are Associated with Measures of Cognitive Ageing in the Lothian Birth Cohorts of 1921 and 1936
Figure 2
The interaction of an SNP pair from BIN1 and APP is likely to influence logical memory in the APOE ε4 positive subset of LBC1936. Analysis of both the (a) genotype cognitive means and (b) the allele specific means shows that the initial positive result is due to two individuals carrying both minor alleles, aabb. Genotype legend; 11 = AaBb, 10 = AaBB, 01 = AABb, 00 = AABB, 12 = Aabb, 01 = AAbb, 21 = aaBb, 20 = aaBB, 22 = aabb. Allele legend; 1 = aabb, 2 = aaB-, 3 = A-bb, 4 = A-B-.
