Alzheimer's Disease Genes Are Associated with Measures of Cognitive Ageing in the Lothian Birth Cohorts of 1921 and 1936

Table 3

Significant pairwise interaction results.

Cohort	Samples	Gene 1	dbSNP ID (rs)	Gene 2	dbSNP ID (rs)	Cognitive phenotype	Beta	P
LBC1936	APOEε4 negative	MARK4	344807	APP	12482753	GCA70	−1.69	.000012*
LBC1921	APOEε4 positive	intergenic chr 19	2627641	APP	2829984	GCA70	−1.21	.000032
		intergenic chr 19	597668	APP	2829984	GCA70	−1.21	.000032
Both	APOE ε4 negative	MARK4	344807	APP	12482753	GCA70	−1.27	.000056
LBC1936	APOEε4 negative	PS1	214260	APP	440666	VF	−0.5	.000012*
LBC1936	APOEε4 negative	PS2	1150895	PICALM	3851179	LM	−0.43	.0000048*
LBC1936	APOEε4 positive	BIN1	10200967	APP	2830036	LM	−0.67	.000011*
LBC1921	Overall	BIN1	10200967	APP	396969	LM	0.62	.00033
		BIN1	10200967	APP	383700	LM	0.62	.00032

A result is significant with the LBC1936 cohort if 𝑃≤.000013 (*) and with the LBC1921 cohort if 𝑃≤.05 (**). The following abbreviations are used: 𝑁, sample number; Beta, regression coefficient of the trait value; GCA70, general cognitive ability at age 70 (MHT adjusted for age); VF, verbal fluency; LM, logical memory.