Alzheimer's Disease Genes Are Associated with Measures of Cognitive Ageing in the Lothian Birth Cohorts of 1921 and 1936

Table 4

Comparison of significant findings between studies.

Gene	Paper	Genotyping method	SNP (rs)	P value	OR	β	Trait
CLU	Harold et al. [8]	Illumina 610 quad Illumina Human Hap550/300	11136000**	8.5 × 10^-10	0.86		LOAD
	Lambert et al. [9]	Illumina 610 quad	11136000	7.5 × 10^-9	0.86		LOAD
	Carrasquillo et al. [11]	Taqman	11136000	8.6 × 10^-5	0.82		LOAD
	Corneveaux et al. [12]	Genome-wide Human SNP6.0 array, Affymetrix	11136000	0.04	0.86		LOAD
	Kamboh et al. [13]	Taqman	11136000	4.4 × 10^-16	0.86		LOAD
	Mengel-From et al. [18]	Taqman	11136000	0.016		0.5	CCS
PICALM	Harold et al. [8]	Illumina 610 quad Illumina Human Hap550/300	3851179**	1.3 × 10^-9	0.86		LOAD
	Carrasquillo et al. [11]	Taqman	3851179	1.3 × 10^-5	0.8		LOAD
	Kamboh et al. [13]	Taqman	3851179	3.4 × 10^-9	0.88		LOAD
	Mengel-From et al. [18]	Taqman	3851179	0.024		1.4	CCS*
	Hamilton et al. 2011	Illumina 610 quad v1.0	3851179 (interaction with PS2)	0.0000048		−0.43	LM
	Corneveaux et al. [12]	Genome-wide Human SNP6.0 array, Affymetrix	541458**	0.01	0.81		LOAD
	Kamboh et al. [13]	Taqman	541458	3.5 × 10^-9	0.87		LOAD
CR1	Lambert et al. [9]	Illumina 610 quad	6656401**	3.7 × 10^-9	1.21		LOAD
	Corneveaux et al. [12]	Genome-wide Human SNP6.0 array, Affymetrix	6656401	0.008	1.28		LOAD
	Kamboh et al. [13]	Taqman	6656401	2.3 × 10^-9	1.17		LOAD
	Carrasquillo et al. [11]	Taqman	3818361**	0.014	1.15		LOAD
	Kamboh et al. [13]	Taqman	3818361	5.2 × 10^-13	1.21		LOAD
BIN1	Seshadri et al. [10]	Illumina 610 quad 6.0 (amongst others)	744373**	1.6 × 10^-11	1.13		LOAD
BIN1	Hamilton et al. 2011	Illumina 610 quad v1.0	10200967 (interaction with APP)	0.000011		−0.67	LM
chr19	Seshadri et al. [10]	Illumina 610 quad 6.0 (amongst others)	597668**	6.4 × 10^-9	1.18		LOAD
	Hamilton et al. 2011	Illumina 610 quad v1.0	7247764, 28555639, 12460041	0.000036		0.016	MR
	Hamilton et al. 2011	Illumina 610 quad v1.0	344807 (interaction with APP)	0.000012			GCA70

Results are provided from recent GWAS for sporadic AD and compared to the results obtained in this study. The following abbreviations are used: OR, odds ratio; Beta, regression coefficient of the trait value; GCA70, general cognitive ability at age 70 (MHT adjusted for age); LM, logical memory; MR, matrix reasoning; LOAD, late-onset Alzheimer’s disease; CCS, cognitive composite score; n/a, not applicable. *observed in males. **included in the LBC1921 and LBC1936 study.