International Journal of Alzheimer’s Disease / 2011 / Article / Tab 4 / Research Article
Alzheimer's Disease Genes Are Associated with Measures of Cognitive Ageing in the Lothian Birth Cohorts of 1921 and 1936 Table 4 Comparison of significant findings between studies.
Gene Paper Genotyping method SNP (rs) P valueOR β Trait CLU Harold et al. [8 ] Illumina 610 quad Illumina Human Hap550/300 11136000** 8.5 × 10-10 0.86 LOAD Lambert et al. [9 ] Illumina 610 quad 11136000 7.5 × 10-9 0.86 LOAD Carrasquillo et al. [11 ] Taqman 11136000 8.6 × 10-5 0.82 LOAD Corneveaux et al. [12 ] Genome-wide Human SNP6.0 array, Affymetrix 11136000 0.04 0.86 LOAD Kamboh et al. [13 ] Taqman 11136000 4.4 × 10-16 0.86 LOAD Mengel-From et al. [18 ] Taqman 11136000 0.016 0.5 CCS PICALM Harold et al. [8 ] Illumina 610 quad Illumina Human Hap550/300 3851179** 1.3 × 10-9 0.86 LOAD Carrasquillo et al. [11 ] Taqman 3851179 1.3 × 10-5 0.8 LOAD Kamboh et al. [13 ] Taqman 3851179 3.4 × 10-9 0.88 LOAD Mengel-From et al. [18 ] Taqman 3851179 0.024 1.4 CCS*
Hamilton et al. 2011 Illumina 610 quad v1.0 3851179 (interaction with PS2 ) 0.0000048 −0.43 LM Corneveaux et al. [12 ] Genome-wide Human SNP6.0 array, Affymetrix 541458** 0.01 0.81 LOAD Kamboh et al. [13 ] Taqman 541458 3.5 × 10-9 0.87 LOAD CR1 Lambert et al. [9 ] Illumina 610 quad 6656401** 3.7 × 10-9 1.21 LOAD Corneveaux et al. [12 ] Genome-wide Human SNP6.0 array, Affymetrix 6656401 0.008 1.28 LOAD Kamboh et al. [13 ] Taqman 6656401 2.3 × 10-9 1.17 LOAD Carrasquillo et al. [11 ] Taqman 3818361** 0.014 1.15 LOAD Kamboh et al. [13 ] Taqman 3818361 5.2 × 10-13 1.21 LOAD BIN1 Seshadri et al. [10 ] Illumina 610 quad 6.0 (amongst others) 744373** 1.6 × 10-11 1.13 LOAD BIN1
Hamilton et al. 2011 Illumina 610 quad v1.0 10200967 (interaction with APP ) 0.000011 −0.67 LM chr19 Seshadri et al. [10 ] Illumina 610 quad 6.0 (amongst others) 597668** 6.4 × 10-9 1.18 LOAD
Hamilton et al. 2011 Illumina 610 quad v1.0 7247764, 28555639, 12460041 0.000036 0.016 MR
Hamilton et al. 2011 Illumina 610 quad v1.0 344807 (interaction with APP ) 0.000012 GCA70
Results are provided from recent GWAS for sporadic AD and compared to the results obtained in this study. The following abbreviations are used: OR, odds ratio; Beta, regression coefficient of the trait value; GCA70, general cognitive ability at age 70 (MHT adjusted for age); LM, logical memory; MR, matrix reasoning; LOAD, late-onset Alzheimer’s disease; CCS, cognitive composite score; n/a, not applicable. *observed in males. **included in the LBC1921 and LBC1936 study.