A Factor Analytic Approach to Symptom Patterns in Dementia

Table 1

Age at onset, age at death, duration of illness (mean ± SD (range)), and gender characteristics in 190 patients with neuropathological dementia diagnosis.

(a)

NP diagnosis	n (%)	Male/Female	Age at onset	Age at death	Duration of illness
			(years)	(years)	(years)
AD	74 (35.4)	20/54	64.2 ± 10.2	74.7 ± 8.7	10.4 ± 4.9
			(44–88)	(59–93)	(1–21)
FTD	52 (24.9)	23/29	54.7 ± 10.9	63.8 ± 11.5	9.1 ± 5.2
			(30–84)	(34–85)	(1–26)
VaD	33 (15.8)	19/14	69.5 ± 9.9	76.5 ± 9.0	7.1 ± 6.4
			(53–89)	(58–93)	(1–26)
Mixed AD/VaD	31 (14.8)	15/16	77.0 ± 6.5	84.3 ± 6.3	7.4 ± 4.0
			(64–92)	(71–97)	(1–15)
Total	190 (100)	77/113	64.6 ± 12.3	73.6 ± 11.5	8.9 ± 5.3
			(30–92)	(34–97)	(1–26)

(b)

Group comparisons (difference (95% CI))	Age at onset^#	Age at death^##	Duration of illness^###
AD versus FTD	9.5 (5.7–13.3)*	10.9 (7.3–14.4)*	1.3 (−0.5–3.1)
AD versus VaD	−5.2 (−9.5–−1.0)*	−1.8 (−5.5–1.8)	3.3 (1.0–5.6)*
AD versus mixed AD/VAD	−12.7 (−16.7–−8.8)*	−9.6 (−13.1–−6.2)*	2.9 (1.0–4.9)*
FTD versus VaD	−14.7 (−19.4–−10.1)*	−12.7 (−17.4–−8.0)*	2.0 (−0.5–4.5)
FTD versus mixed AD/VaD	−22.2 (−26.5–−17.9)*	−20.5 (−25.0–−16.1)*	1.7 (−0.5–3.8)
VaD versus mixed AD/VaD	−7.5 (−11.7–−3.3)*	−7.8 (−11.7–−3.9) *	−0.4 (−3.0–2.3)

^#ANOVA F_3,184 = 36 (P <  .001)
^##ANOVA F_3,186 = 34 (P <  .001)
^###ANOVA F_3,184 = 4 (P <  .007)
*Significant difference (P <  .05) Student-Newman-Keuls test.