Multimodal Imaging of Alzheimer Pathophysiology in the Brain's Default Mode Network
Figure 1
The brain’s default network was originally identified in a meta-analysis that mapped brain regions more active in passive as compared to active tasks (often referred to as task-induced deactivation). The displayed [O-15]H2O positron emission tomography (PET) data include nine studies (132 young adults) from Shulman et al. [30] (reanalyzed in [21]). Images show the medial and lateral surface of the left hemisphere using a population-averaged surface representation to take into account between-subject variability in sulcal anatomy. Blue represents regions most active in passive task settings. Adapted and reprinted with permission from Buckner et al. [4, 21] [Copyright (2005) Journal of Neuroscience].
