Beta-Amyloid Downregulates MDR1-P-Glycoprotein (Abcb1) Expression at the Blood-Brain Barrier in Mice
Figure 1
mRNA expression of Abcb1a (a), Abcg2 (b), LRP1 (c), and RAGE (d) in murine brain. Mice were treated with β-amyloid 1-42 (Aβ1-42), reverse β-amyloid 42-1 (Aβ42-1) and vehicle control (control) using ALZET pumps for 24 h (4 μg/h). mRNA expression of each transporter was normalized to 18S rRNA expression and values are depicted in relation to the median expression in vehicle perfused mice. Statistical analysis was performed by one-way ANOVA followed by Newmann-Keuls Multiple Comparison test.
