Beta-Amyloid Downregulates MDR1-P-Glycoprotein (Abcb1) Expression at the Blood-Brain Barrier in Mice
Figure 2
mRNA expression of Abcb1a (a), Abcg2 (b), LRP1 (c) and RAGE (d) in murine brain. Mice were treated with β-amyloid 1-40 (Aβ1-40), reverse-sequence β-amyloid 40-1 (Aβ40-1) and vehicle control (control) using ALZET pumps for 24 h (4 μg/h). mRNA expression of each transporter was normalized to 18S rRNA expression, and values are depicted in relation to the median expression in vehicle-perfused mice. Statistical analysis was performed by one-way ANOVA followed by Newmann-Keuls Multiple Comparison test.
