Specific Silencing of L392V PSEN1 Mutant Allele by RNA Interference

Figure 3

The sequences of the antisense strands of siRNAs used in studies. The guide strand of each siRNA is fully complementary to the mutant (C→G) PSEN1 transcript and it has one mismatch (C:C) in respect to the wild type gene. The region between 2nd to 8th nucleotide, counted from the 5′-end of the antisense strand of siRNA is known as the seed region.