Copper Inhibits NMDA Receptor-Independent LTP and Modulates the Paired-Pulse Ratio after LTP in Mouse Hippocampal Slices
Figure 3
Modulation of the PPR by copper in the CA1 and CA3 regions was dependent on LTP. (a) The average of the PPRs measured 30 minutes before tetanizing the slices was not different in copper-treated (white bars), compared to control slices (gray bars) in either the CA1 or CA3 region. Also, the PPRs in control slices did not change after LTP in either brain region. However, after LTP, copper-treated slices showed a 34.9% enhancement of the PPR in the CA1 region (, ) and a 29.3% decrease in the PPR in the CA3 region (, ). (b) Without the HFS, there was no significant change in the PPRs compared between control and copper-treated slices in either the CA1 or CA3 region.
