Possible Role of the Transglutaminases in the Pathogenesis of Alzheimer's Disease and Other Neurodegenerative Diseases
Figure 1
Transglutaminase-catalyzed reactions. Examples of TG-catalyzed reactions: (a) acyl transfer between the γ-carboxamide group of a protein/polypeptide glutaminyl residue and the ε-amino group of a protein/polypeptide lysyl residue; (b) attachment of a polyamine to the carboxamide group of a glutaminyl residue; (c) deamidation of the γ-carboxamide group of a protein/polypeptide glutaminyl residue.
