Possible Role of the Transglutaminases in the Pathogenesis of Alzheimer's Disease and Other Neurodegenerative Diseases

Table 1

TG enzymes and their biological functions when known.

TG	Physiological role	Gene map location	Reference
Factor XIIIa	Blood clotting	6p24-25	[10]
TG 1 (Keratinocyte TG, kTG)	Skin differentiation	14q11.2	[11]
TG 2 (Tissue TG, tTG, cTG)	Apoptosis, cell adhesion, signal transduction	20q11-12	[12]
TG 3 (Epidermal TG, eTG)	Hair follicle differentiation	20p11.2	[13]
TG 4 (Prostate TG, pTG)	Suppression of sperm immunogenicity	3q21-2	[14]
TG 5 (TG X)	Epidermal differentiation	15q15.2	[15]
TG 6 (TG Y)	Unknown function	20p13	[15]
TG 7 (TG Z)	Unknown function	15q15.2	[15]