Psychosis in Alzheimer's Disease in the National Alzheimer's Disease Coordinating Center Uniform Data Set: Clinical Correlates and Association with Apolipoprotein E
Table 2
Demographic and clinical characteristics and their association with AD+P with Never Psychotic (AD−P) cases restricted to .
Variable
Psychosis status
Total (%) or mean (SD)
or
df
value
Never (%) or mean (SD)
Single (%) or mean (SD)
Multiple/Recurrent (%) or mean (SD)
Age
78.8 (6.8)
79.0 (7.1)
78.3 (7.1)
78.7 (6.9)
0.886‡
.413
Age of onset
73.4 (6.9)
73.4 (7.1)
72.3 (6.9)
73.2 (7.0)
3.094‡
.046
Sex
14.035†
2
.001
Male
529 (46.4)
188 (38.1)
116 (37.5)
833 (42.9)
Female
610 (53.6)
305 (61.9)
193 (62.5)
1108 (57.1)
Race
83.311†
4
<.001
Caucasian
1024 (90.0)
394 (79.9)
216 (70.0)
1634 (84.2)
African-American
87 (7.6)
76 (15.4)
69 (22.3)
232 (12.0)
Other
27 (2.4)
23 (4.7)
24 (7.7)
74 (3.8)
Hispanic
15.243†
2
<.001
No
1069 (93.9)
448 (90.9)
270 (87.4)
1787 (92.1)
Yes
70 (6.1)
45 (9.1)
39 (12.6)
154 (7.9)
Primary language
11.252†
2
.004
English
1070 (93.9)
455 (92.3)
273 (88.3)
1798 (92.6)
Other
69 (6.1)
38 (7.7)
36 (11.7)
143 (7.4)
Education
14.2 (3.6)
13.4 (3.6)
13.0 (4.2)
13.8 (3.7)
16.762‡
<.001
MMSE
16.9 (6.5)
16.8 (7.0)
14.2 (7.1)
16.4 (6.8)
19.386‡
<.001
CDR (global)
186.669†
6
<.001
0.0
0 (0.0)
0 (0.0)
0 (0.0)
0 (0.0)
0.5
0 (0.0)
52 (10.5)
12 (3.9)
64 (3.3)
1.0
583 (51.2)
192 (39.0)
83 (26.9)
858 (44.2)
2.0
408 (35.8)
182 (36.9)
132 (42.7)
722 (37.2)
3.0
148 (13.0)
67 (13.6)
82 (26.5)
297 (15.3)
Hachinski
1.1 (1.4)
1.1 (1.3)
1.3 (1.5)
1.1 (1.4)
1.864‡
.155
GDS
2.1 (2.3)
2.5 (2.9)
2.7 (3.0)
2.3 (2.6)
6.947‡
.001
APOE ϵ4 allele carrier status
3.100†
2
.212
−ϵ4
471 (41.4)
190 (38.5)
112 (36.2)
773 (39.8)
+ϵ4
668 (58.6)
303 (61.5)
197 (63.8)
1168 (60.2)
APOE ϵ4 allele number
3.502†
4
.478
0
471 (41.3)
190 (38.5)
112 (36.3)
773 (39.8)
1
527 (46.3)
236 (47.9)
158 (51.1)
921 (47.5)
2
141 (12.4)
67 (13.6)
39 (12.6)
247 (12.7)
Abbreviations: AD+P, Alzheimer’s disease plus psychosis; AD−P, Alzheimer’s disease minus psychosis; MMSE, Mini-mental state exam; CDR, Clinical dementia rating scale; GDS, Geriatric depression scale; APOE, Apolipoprotein E. Pearson’s Chi-square test: values are presented. One-way analysis of variance: values are presented.
