Research Article
Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain
Table 3
Fold changes and
values when comparing tg-ArcSwe mice and nontransgenic littermates and when comparing AD patients and control subjects (C).
| Gene | Protein | Tg-ArcSwe versus nontransgenic | AD versus C | Microarray | qPCR | qPCR | Fold change | | Fold change | | Fold change | |
| CCND3 | Cyclin D3 | 1.10 | <.05 | 0.88 | n.s. | 1.14 | n.s. | LEF1 | Lymphoid enhancer-binding factor 1 | 0.92 | <.05 | 0.88 | n.s. | 0.90 | n.s. | MYC | V-myc myelocytomatosis viral oncogene homolog | 1.09 | <.05 | 0.91 | n.s. | 2.02 | <.05 | NFAT5 | Nuclear factor of activated T-cells 5 | 0.91 | <.05 | 0.96 | n.s. | 1.21 | n.s. | NKD2 | Naked cuticle homolog 2 (Drosophila) | 1.08 | <.05 | 1.05 | n.s. | 0.92 | n.s. | PLCB1 | Phospholipase C, beta 1 | 0.90 | <.01 | 0.99 | n.s. | 0.82 | n.s. | PPP2R2C | Protein phosphatase 2, regulatory subunit B, gamma | 0.93 | <.05 | 1.21 | n.s. | 1.24 | n.s. | PPP3CB | Protein phosphatase 3, catalytic subunit | 1.08 | <.05 | 1.03 | n.s. | 0.79 | n.s. | TCF7L2 | Transcription factor 7-like 2 | 1.10 | <.05 | 0.95 | n.s. | 1.43 | <.05 |
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n.s.: not significant.
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