Formation of Toxic Amyloid Fibrils by Amyloid β-Protein on Ganglioside Clusters

Table 1

Parameters for the binding of DAC-Aβs to GM1/cholesterol/SM (1 : 1 : 1) LUVs at 37°C.

Aβ	K (10^6 M^-1)^a	𝑥max   ^b(Aβ/GM1, mol/mol)	Ref.
DAC-Aβ-(1–42)	11.1 ± 2.4	0.0361 ± 0.0021	[17]
DAC-Aβ-(1–40)	8.6 ± 3.6	0.0313 ± 0.0041	[16]
DAC-Aβ-(1–28)	0.0184 ± 0.0007	0.0313^c	[16]

^aBinding constant
^bMaximal value of x (bound Aβ per exofacial GM1, mol/mol)
^cAssumed to be the same as that of DAC-Aβ-(1–40).