Cell Surface Binding and Internalization of Aβ Modulated by Degree of Aggregation

Figure 6

Percentage of PC12 cells with internalized Aβ. Aβ40²⁴ and Aβ42²⁴ were more significantly internalized into differentiated PC12 cells than the other forms of Aβ. Aβ40⁹⁰ and Aβ42⁹⁰ display a striking drop in the amount of internalization. Error bars represent the standard deviation from at least three individual experiments with 𝑛>200 cells per condition. Statistical significance is indicated (*) 𝑃<.005.