Cell Surface Binding and Internalization of Aβ Modulated by Degree of Aggregation
Figure 7
Inhibition of Aβ internalization. Confocal microscopy images of differentiated PC12 cells treated with Aβ40/4224 for 4 hours. All scale bars are 20 μm in length. Internalization was only observed at 37°C. Membrane integrity was maintained throughout all treatments, indicating that internalization is mediated through a cellular process such as clathrin-dependent endocytosis.
