Simvastatin Blocks Blood-Brain Barrier Disruptions Induced by Elevated Cholesterol Both In Vivo and In Vitro
Figure 1
Simvastatin blocks high-cholesterol diet-induced leakage of Evan’s blue dye. New Zealand White rabbits were fed a normal diet (10 weeks) or a high-cholesterol diet (10 weeks) with or without simvasatin (over the final 4 weeks). After treatment, BBB permeability was evaluated by measuring Evan’s blue dye leakage. High-cholesterol diet significantly increased the leakage of Evan’s blue dye into the olfactory bulbs and hippocampus, and these effects were attenuated by treatment with simvastatin (5 mg/kg/day during weeks 7–10) (, *; **).
