Will Posttranslational Modifications of Brain Proteins Provide Novel Serological Markers for Dementias?

Figure 1

Schematic illustration of the alterations in neuronal integrity (black line) and subsequent loss of cognitive function (red line). The green boxes indicate at what level the presently available biomarkers have diagnostic/prognostic value, that is, once cognitive decline has begun, and at which level it is desired to be able to provide a prognosis/diagnosis, that is, biomarkers monitoring very early changes in neuronal integrity.