Will Posttranslational Modifications of Brain Proteins Provide Novel Serological Markers for Dementias?

Table 2

BIPED classification adopted from [36].

Burden of disease:	Burden-of-disease markers assess the severity or extent of disease
Investigative:	A marker which does not have a clear-cut pathological relevance, but is used exploratively
Prognostic:	The key feature of a prognostic marker is the ability to predict the future onset of disease
Efficacy of intervention:	An efficacy-of-intervention biomarker provides information about the efficacy of treatment or those at high risk for its development
Diagnostic:	Diagnostic markers are defined by the ability to classify individuals as either having or not having a disease