Table 1: GSMs do not show a potency shift with APP overexpression.

Cell lineH4H4-APPCHO-SWCHO-7WCHO-2B7

A Levels (pg/mL)20110131834200

InhibitorsA IC50 (nM) per cell line

LY4115751.401.200.20ND0.05
GSI-953706525.208.702.50
BMS-7081634080.981.100.20

ModulatorsA IC50 (nM) per cell line

GSM154641547362
JNJ-40418677115133190122172
E-20124284543633