Modulation of Gamma-Secretase for the Treatment of Alzheimer's Disease

Table 1

GSMs do not show a potency shift with APP overexpression.

Cell line	H4	H4-APP	CHO-SW	CHO-7W	CHO-2B7
A𝛽42 Levels (pg/mL)	20	110	131	834	200
Inhibitors	A𝛽42 IC50 (nM) per cell line
LY411575	1.40	1.20	0.20	ND	0.05
GSI-953	706	52	5.20	8.70	2.50
BMS-708163	40	8	0.98	1.10	0.20
Modulators	A𝛽42 IC50 (nM) per cell line
GSM1	54	64	154	73	62
JNJ-40418677	115	133	190	122	172
E-2012	42	84	54	36	33