Table 2: GSM potency versus plasma exposure in mice.

E-2012JNJ-40418677GSM1SPI-1810

In vitro A IC50 (nM) CHO-2B7 cells3317262114
Plasma exposure ( M)49237764274414638
Plasma fold over A IC50 for 25% reduction1494544128
Brain exposure ( M)27497497868120368
Brain fold over A IC50 for 25% reduction8344140179