Japanese Alzheimer’s Disease and Other Complex Disorders Diagnosis Based on Mitochondrial SNP Haplogroups

Table 3

(a) mtDNA mutations for the haplogroups of the AD patients, (b) mtDNA mutations for the haplogroups of the PD patients, (c) mtDNA mutations for the haplogroups of the T2D patients, (d) mtDNA mutations for the haplogroups of the T2D patients with angiopathy, (e) mtDNA mutations for the haplogroups of the centenarians, (f) mtDNA mutations for the haplogroups of the semi-supercentenarians, (g) mtDNA mutations for the haplogroups of the non-obese young males, (h) mtDNA mutations for the haplogroups of the obese young males.

(a)

mtDNA locus	Normal nucleotide	mtDNA mutation	AD patients
			G2a	N9b1
709	G	A	A
4833	A	G	G
5108	T	C	C
5147	G	A		A
5417	G	A		A
5601	C	T	T
7600	G	A	A
9377	A	G	G
9575	G	A	A
10607	C	T		T
11016	G	A		A
13183	A	G		G
13563	A	G	G
14200	T	C	C
14569	G	A	A
14893	A	G		G
16278	C	T	T
16362	T	C	C
16519	T	C	C

(b)

mtDNA locus	Normal nucleotide	mtDNA mutation	PD patients
			M7a1a	G1a	B5b	N9a
150	C	T		T		T
204	T	C			C
709	G	A			A
1598	G	A			A
2626	T	C	C
2772	C	T	T
4386	T	C	C
4958	A	G	G
5231	G	A				A
5417	G	A				A
7867	C	T		T
8020	G	A		A
8584	G	A			A
9950	T	C			C
11017	T	C	C
11084	A	G	G
12358	A	G			G
12361	A	G			G
12372	G	A				A
12771	G	A	A
14364	G	A	A
15223	C	T			T
15323	G	A		A
15851	A	G			G
15927	G	A			A
16140	T	C			C
16209	T	C		C
16243	T	C			C
16257	C	A				A
16261	C	T				T
16324	T	C	C
16519	T	C	C

(c)

mtDNA locus	Normal nucleotide	mtDNA mutation	T2D patients
			M8a	D4b2b	B5b
194	C	T		T
204	T	C			C
709	G	A			A
1382	A	C		C
1598	G	A			A
3010	G	A		A
4715	A	G	G
4883	C	T		T
5178	C	A		A
6179	G	A	A
7196	C	A	A
8020	G	A		A
8414	C	T		T
8584	G	A	A		A
8684	C	T	T
8829	C	T			T
8964	C	T		T
9296	C	T		T
9824	T	A		A
9950	T	C			C
12361	A	G			G
14470	T	C	C
14605	A	G		G
14668	C	T		T
15223	C	T			T
15487	A	T	T
15508	C	T			T
15662	A	G			G
15851	A	G			G
15927	G	A			A
16140	T	C			C
16243	T	C			C
16298	T	C	C
16319	G	A	A
16519	T	C	C	C

(d)

mtDNA locus	Normal nucleotide	mtDNA mutation	T2D patients with angiopathy
			G2a	D4b1	N9a2
150	C	T			T
709	G	A	A
3010	G	A		A
4833	A	G	G
4883	C	T		T
5108	T	C	C
5178	C	A		A
5231	G	A			A
5417	G	A			A
5601	C	T	T
7600	G	A	A
8020	G	A		A
8414	C	T		T
9377	A	G	G
9575	G	A	A
10181	C	T		T
12358	A	G			G
12372	G	A			A
13563	A	G	G
14569	G	A	A
14668	C	T		T
15440	T	C		C
15951	A	G		G
16172	T	C			C
16257	C	A			A
16261	C	T			T
16278	C	T	T
16319	G	A		A
16362	T	C	C	C
16519	T	C	C	C	C

(e)

mtDNA locus	Normal nucleotide	mtDNA mutation	Centenarians
			M7b2	D4b2a	B5b
150	C	T	T
199	T	C		C
204	T	C	C
709	G	A			A
1382	A	C		C
1598	G	A			A
3010	G	A		A
4048	G	A	A
4071	C	T	T
4164	A	G	G
4883	C	T		T
5178	C	A		A
5351	A	G	G
5460	G	A	A
6455	C	T	T
6680	T	C	C
7684	T	C	C
7853	G	A	A
8020	G	A		A
8251	G	A		A
8414	C	T		T
8584	G	A			A
8829	C	T			T
8964	C	T		T
9824	T	A		A
9824	T	C		C
9950	T	C			C
10104	C	T		T
10345	T	C	C
12361	A	G			G
12405	C	T	T
12705	C	T			T
12811	T	C	C
14668	C	T		T
15223	C	T			T
15508	C	T			T
15662	A	G			G
15851	A	G			G
15927	G	A			A
16129	G	A	A
16140	T	C			C
16223	C	T			T
16243	T	C			C
16297	T	C	C
16298	T	C	C
16362	T	C		C
16519	T	C		C	C

(f)

mtDNA locus	Normal nucleotide	mtDNA mutation	Semi-supercentenarians
			M1	B4c1a	B4c1b1	B4c1c1	F1
150	C	T			T	T
195	T	C	C			C
709	G	A		A
1119	T	C		C	C	C
1621	T	C		C	C	C
3497	C	T		T	T
3970	C	T					T
6392	T	C					C
6962	G	A					A
10310	G	A		A			A
10398	A	G				G
10609	G	A					A
12406	G	A					A
12705	C	T		T	T	T	T
12802	C	T					T
13928	G	C					C
15346	G	A		A
16140	T	C			C
16217	T	C		C	C	C
16223	C	T		T	T	T	T
16249	T	C	C
16274	G	A			A
16311	T	C	C	C
16519	T	C		C	C	C	C

(g)

mtDNA locus	Normal nucleotide	mtDNA mutation	Non-obese young males
			D4b2b	D4g	B4b/d/e	N9a
150	C	T				T
194	C	T	T
827	A	G			G
1382	A	C	C
3010	G	A		A
4343	A	G		G
4883	C	T	T	T
5178	C	A	A	A
5231	G	A				A
5417	G	A				A
8020	G	A	A
8414	C	T		T
8701	A	G		G
8964	C	T	T
9296	C	T	T
9824	T	A	A
12358	A	G				G
12372	G	A				A
12705	C	T			T
13104	A	G		G
14668	C	T	T	T
15518	C	T		T
15535	C	T			T
16217	T	C			C
16223	C	T			T
16257	C	A				A
16261	C	T				T
16278	C	T		T
16362	T	C	C	C
16519	T	C	C	C	C	C

(h)

			Obese young males
mtDNA locus	Normal nucleotide	mtDNA mutation	M7a1a	M7b2	D4b2b	B4c1
150	C	T		T
194	C	T			T
199	T	C		C
709	G	A				A
1119	T	C				C
1382	A	C			C
2626	T	C	C
2772	C	T	T
3010	G	A			A
3497	C	T				T
4048	G	A		A
4071	C	T		T
4164	A	G		G
4386	T	C	C
4883	C	T			T
4958	A	G	G
5178	C	A			A
5351	A	G		G
5460	G	A		A
6455	C	T	T	T
6680	T	C		C
7684	T	C		C
7853	G	A		A
8020	G	A			A
8964	C	T			T
9296	C	T			T
9824	T	A			A
10345	T	C		C
12405	C	T		T
12705	C	T				T
12771	G	A	A
12811	T	C		C
14668	C	T			T
15346	G	A				A
16129	G	A		A
16209	T	C	C
16217	T	C				C
16223	C	T				T
16297	T	C		C
16298	T	C		C
16324	T	C			C
16362	T	C			C
16519	T	C		C	C