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International Journal of Alzheimer’s Disease
Volume 2012 (2012), Article ID 251426, 13 pages
http://dx.doi.org/10.1155/2012/251426
Review Article

Protein Tau: Prime Cause of Synaptic and Neuronal Degeneration in Alzheimer's Disease

Experimental Genetics Group (LEGTEGG), Department of Human Genetics, KU Leuven, Campus Gasthuisberg ON1-06.602, Herestraat 49, 3000 Leuven, Belgium

Received 14 February 2012; Accepted 16 March 2012

Academic Editor: Rakez Kayed

Copyright © 2012 Natalia Crespo-Biel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [14 citations]

The following is the list of published articles that have cited the current article.

  • Clara Theunis, Natalia Crespo-Biel, Valerie Gafner, Maria Pihlgren, Maria Pilar Lopez-Deber, Pedro Reis, David T. Hickman, Oskar Adolfsson, Nathalie Chuard, Dorin Mlaki Ndao, Peter Borghgraef, Herman Devijver, Fred Van Leuven, Andrea Pfeifer, and Andreas Muhs, “Efficacy and Safety of A Liposome-Based Vaccine against Protein Tau, Assessed in Tau.P301L Mice That Model Tauopathy,” Plos One, vol. 8, no. 8, 2013. View at Publisher · View at Google Scholar
  • Qiu-Yan Liu, Jin-Tai Yu, Dan Miao, Xiao-Ying Ma, Hui-Fu Wang, Wei Wang, and Lan Tan, “An exploratory study on STX6, MOBP, MAPT, and EIF2AK3 and late-onset Alzheimer's disease,” Neurobiology of Aging, vol. 34, no. 5, pp. 1519.e13–1519.e17, 2013. View at Publisher · View at Google Scholar
  • Wenjia Lai, Jing Wu, Xiao Zou, Jian Xie, Liwei Zhang, Xuyang Zhao, Minzhi Zhao, Qingsong Wang, and Jianguo Ji, “Secretome Analyses of A beta(1-42) Stimulated Hippocampal Astrocytes Reveal that CXCL10 is Involved in Astrocyte Migration,” Journal Of Proteome Research, vol. 12, no. 2, pp. 832–843, 2013. View at Publisher · View at Google Scholar
  • Pu Fang, Wenyuan Xu, Chengsi Wu, Min Zhu, Xiaobing Li, and Daojun Hong, “MAPT as a predisposing gene for sporadic amyotrophic lateral sclerosis in the Chinese Han population,” Neural Regeneration Research, vol. 8, no. 33, pp. 3116–3123, 2013. View at Publisher · View at Google Scholar
  • Manjinder Singh, Maninder Kaur, Hitesh Kukreja, Rajan Chugh, Om Silakari, and Dhandeep Singh, “Acetylcholinestrase Inhibitors as Alzheimer Therapy: From Nerve Toxins to Neuroprotection,” European Journal of Medicinal Chemistry, 2013. View at Publisher · View at Google Scholar
  • Wolfgang Froestl, Andrea Pfeifer, and Andreas Muhs, “Cognitive Enhancers (Nootropics). Part 3: Drugs Interacting with Targets other than Receptors or Enzymes. Disease-modifying Drugs,” Journal Of Alzheimers Disease, vol. 34, no. 1, pp. 1–114, 2013. View at Publisher · View at Google Scholar
  • Benoît Leclerc, and Abedelnasser Abulrob, “Perspectives in Molecular Imaging Using Staging Biomarkers and Immunotherapies in Alzheimer’s Disease,” The Scientific World Journal, vol. 2013, pp. 1–16, 2013. View at Publisher · View at Google Scholar
  • Pradip K. Kamat, Chandishwar Nath, and Shivika Rai, “Okadaic acid induced neurotoxicity: An emerging tool to study Alzheimer's disease pathology,” Neurotoxicology, vol. 37, pp. 163–172, 2013. View at Publisher · View at Google Scholar
  • Bruno Bulic, Marcus Pickhardt, and Eckhard Mandelkow, “Progress and Developments in Tau Aggregation Inhibitors for Alzheimer Disease,” Journal Of Medicinal Chemistry, vol. 56, no. 11, pp. 4135–4155, 2013. View at Publisher · View at Google Scholar
  • Natalia Crespo-Biel, Clara Theunis, Peter Borghgraef, Benoit Lechat, Herman Devijver, Herve Maurin, and Fred Van Leuven, “Phosphorylation of protein Tau by GSK3 beta prolongs survival of bigenic Tau.P301L x GSK3 beta mice by delaying brainstem tauopathy,” Neurobiology of Disease, vol. 67, pp. 119–132, 2014. View at Publisher · View at Google Scholar
  • Mansour Akbari, Guido Keijzers, Scott Maynard, Morten Scheibye-Knudsen, Claus Desler, Ian D. Hickson, and Vilhelm A. Bohr, “Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair,” Dna Repair, vol. 16, pp. 44–53, 2014. View at Publisher · View at Google Scholar
  • Hervé Maurin, Benoit Lechat, Peter Borghgraef, Herman Devijver, Tomasz Jaworski, and Fred Van Leuven, “Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3α/β,” European Journal of Neuroscience, 2014. View at Publisher · View at Google Scholar
  • Herve Maurin, Seon-Ah Chong, Igor Kraev, Heather Davies, Anna Kremer, Claire Marie Seymour, Benoit Lechat, Tomasz Jaworski, Peter Borghgraef, Herman Devijver, Geert Callewaert, Michael G. Stewart, and Fred Van Leuven, “Early Structural and Functional Defects in Synapses and Myelinated Axons in Stratum Lacunosum Moleculare in Two Preclinical Models for Tauopathy,” Plos One, vol. 9, no. 2, 2014. View at Publisher · View at Google Scholar
  • Wolfgang Froestl, Andrea Pfeifer, and Andreas Muhs, “Cognitive Enhancers (Nootropics). Part 3: Drugs Interacting with Targets other than Receptors or Enzymes. Disease-Modifying Drugs. Update 2014,” Journal of Alzheimers Disease, vol. 42, no. 4, pp. 1079–1149, 2014. View at Publisher · View at Google Scholar