Mild Cognitive Impairment: Statistical Models of Transition Using Longitudinal Clinical Data
Table 5
Estimated relative risks and 95% confidence intervals for one-step transitions to dementia or death without dementia versus the base state of normal cognition or clinical consensus MCI (MCICC) (bolding denotes statistical significance).
Risk factors* (normal is base state; no history of MCICC)
Dementia versus normal
Death versus normal
Age
1.19 (1.14–1.24)
1.18 (1.15–1.21)
Female sex (versus male)
1.87 (0.95–3.68)
0.68 (0.49–0.95)
Family history of dementia (yes versus no)
1.66 (0.92–3.01)
0.82 (0.57–1.17)
≥one APOE-4 allele (versus none)
2.33 (1.28–4.23)
0.97 (0.67 –1.42)
≤12 years of education (versus >12 years)
0.75 (0.26–2.18)
1.33 (0.80 –.22)
History of hypertension (yes versus no)
0.79 (0.42–1.49)
1.49 (1.07–2.08)
aMCITB at prior assessment (versus normal)
1.85 (0.82–4.21)
0.64 (0.38–1.08)
mMCITB at prior assessment (versus normal)
4.90 (2.58–9.30)
2.67 (1.88–3.79)
Risk factors (MCICCis base state)
Dementia versus MCICC
Death versus MCICC
Age
1.05 (0.98–1.13)
1.03 (0.94–1.13)
Female sex (versus male)
1.75 (0.67–4.56)
1.15 (0.65–3.76)
Family history of dementia (yes versus no)
2.88 (0.95–8.72)
0.68 (0.15–3.03)
≥one APOE-4 allele (versus none)
0.69 (0.22–2.16)
2.33 (0.61–8.90)
≤12 years of education (versus >12 years)
0.97 (0.27–3.46)
0.55 (0.10–2.99)
History of hypertension (yes versus no)
0.30 (0.10–0.93)
0.70 (0.20–2.47)
*As risk factors depend only on the base state, covariate effects in the top half of the table are the same whether transitions occur from a prior state of normal cognition, aMCITB, or mMCITB.
