𝛾-Secretase Modulators: Can We Combine Potency with Safety?

Figure 3

Effects of a single oral dose of 10 mg/kg JNJ-42601572 on Aβ levels in nontransgenic mouse brain as measured with differential ELISAs [16]. Mean (+SEM) brain Aβ levels after drug treatment are expressed as percentage of Aβ levels in brain of vehicle-treated mice. (𝑛=6 mice per data point). BQL: below quantifiable limits (in brain 0.07–0.12 μM).

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