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Figure 1: “Good” versus “Bad” microglia in Alzheimer disease. Illustration using 3D models of ramified “good” microglia and ovoid “bad” microglia along with the array of immune molecules that likely help to determine which activated form of microglia will respond to AD-like pathological lesions. It is postulated that microglial phenotype can interconvert between ramified and ovoid functional states. The 3D images were generated using Imaris: Bitplane 3D modeling software and are provided courtesy of David Gate.