Insulin Receptor Expression and Activity in the Brains of Nondiabetic Sporadic Alzheimer’s Disease Cases
Figure 1
Stability of phosphorylated IRβ in mouse brain specimens as a function of postmortem interval. Mice were sacrificed and brain specimens were isolated immediately. Freshly isolated mouse brain specimens were either rapidly frozen or were kept at room temperature for up to a 6 hr postmortem interval. Samples were assessed at 2 hr postmortem intervals as indicated. Bar graphs represent the ratio of [Tyr1150/1151]-phosphorylated IRβ/total IRβ as mean ± SEM values. ANOVA; ; Inset: representative western blot analysis of [Tyr1150/1151]-phosphorylated IRβ and total IRβ at different postmortem time intervals as indicated.
