Insulin Receptor Expression and Activity in the Brains of Nondiabetic Sporadic Alzheimer’s Disease Cases
Figure 3
Total IRβ and [Tyr1162/1163]-phosphorylated IRβ contents in the hippocampal formation are not correlated with the contents of Aβ peptides. In ((a) and (b)), correlation analysis of total IRβ content with contents of Aβ 1–42 (a) and Aβ 1–40 (b) peptides in the hippocampal formation. In ((c) and (d)), correlation analysis of [Tyr1162/1163]-phosphorylated IRβ contents with Aβ 1–42 (c) and Aβ 1–40 (d) peptides in the hippocampal formation. In ((a)–(d)), solid line represents the best-fit correlation between IRβ or [Tyr1162/1163]-phosphorylated IRβ with β 1–42 or Aβ 1–40 peptides. Pearson correlation analysis; and .271 for IRβ contents with Aβ 1–42 and Aβ 1–40, respectively; and .681 for [Tyr1162/1163]-phosphorylated IRβ contents with Aβ 1–42 and Aβ 1–40, respectively.
