Insulin Receptor Expression and Activity in the Brains of Nondiabetic Sporadic Alzheimer’s Disease Cases
Figure 4
Total IRβ and [Tyr1162/1163]-phosphorylated IRβ contents in the brain are not correlated with the severity of AD-type neuropathology. AD-type neuritic plaque (NP) and neurofibrillary tangle (NFT) neuropathology were assessed using CERAD rating scales. In ((a) and (c)), correlation analysis of total IRβ content with NP (a) and NFT (c) neuropathology in the brain. In ((b) and (d)), correlation analysis of [Tyr1162/1163]-phosphorylated IRβ contents with NP (b) and NFT (d) neuropathology. In ((a)–(d)), solid line represents the best-fit correlation between IRβ or [Tyr1162/1163]-phosphorylated IRβ with NP or NFT neuropathology. Pearson correlation analysis; and .516 for IRβ contents with NP and NFT neuropathology, respectively; and .912 for [Tyr1162/1163]-phosphorylated IRβ contents with NP and NFT neuropathology, respectively.
