Insulin Receptor Expression and Activity in the Brains of Nondiabetic Sporadic Alzheimer’s Disease Cases

Table 1

Characteristics of study subjects¹.

	No. of	Mean ± SEM	Mean ± SEM		Median CERAD	Median CERAD
CDR Score	subjects	Postmortem interval, h	Age, y	Female, %	Plague rating	Tangle rating
0	10	5.44±0.91	80.40±6.02	70%	0	0
0.5	9	4.30±0.40	87.33±2.59	67%	3	0
1	11	4.63±0.69	85.00±3.33	55%	3	0
2	13	4.89±0.87	87.08±1.92	85%	5	3
5	19	4.82±0.72	83.06±2.37	74%	5	3

¹Only nondiabetic cases are selected for this study; cases with a premorbid history of diabetes are excluded. Subjects are grouped by Clinical Dementia rating (CDR). Neuropathology is assessed using Consortium to Establish A Registry for Alzheimer’s Disease (CERAD) ratings. Age and postmortem interval (PMI) are in years.