The Amyloid Precursor Protein Intracellular Domain-Fe65 Multiprotein Complexes: A Challenge to the Amyloid Hypothesis for Alzheimer's Disease?

Table 1

Fe65 interactors and its functions.

Protein	Domain involved	Putative functions of the interaction	References
Amyloid precursor protein (APP)	PTB2	Regulation of Aβ secretion, nuclear signaling, and cytoskeleton regulation	[17]
Mammalian enabled (Mena)	WW	Actin polimerization	[20]
CP2/LSF/LBP1	PTB1	Transcriptional regulation, GSK-3β expression	[21]
Low-density lipoprotein receptor-related protein (LRP1)	PTB1	APP trafficking, Aβ secretion	[22]
Abl tyrosine kinase	WW	Nuclear signaling	[23]
Tat-interacting protein 60 kDa (Tip60)	PTB1	Nuclear signaling, DNA repair	[24]
Alcadein	ND	APP metabolism	[25]
Nucleosome assembly factor SET	WW	Transcriptional regulation	[26]
Tau	PTB1	Cytoskeleton regulation	[27]
14-3-3γ	Between WW and PTB1	Nuclear signaling	[28]
P2X receptor	WW	Synaptic transmission	[29]
ApoER2	PTB1	APP trafficking, Aβ secretion	[30]
Estrogen receptor α	ND	Transcriptional regulation	[31]
NIMA-related kinase 6	WW	Apoptosis	[32]
Glycogen synthase kinase-3β	WW	Kinase activation	[33]
Dexras1	PTB2	Nuclear signaling	[34]
Teashirt	PTB1	Repression of caspase 4 expression	[35]
Neuronal precursor cell expressed developmentally down regulated 4-2 (Nedd 4-2)	WW	Fe65 ubiquitylation	[36]
Dab1	ND	APP processing	[37]
Megalin	ND	Axonal branching, APP trafficking	[38]
Rac1	ND	Fe65 expression	[39]

ND: Not determined