Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease Models

Table 4

Examples of maleimide inhibitors with biological activity against GSK-3, selectivity, X-ray and reference.

No.	X	R^1	IC50 (nM)	Kinase panel	In vivo	X-ray	Year/lit.
28	N	Et	β: 304	β + 21	Yes	1UV5^a	2009 [49]
29	CH	Et	β: 92	β + 2	Yes	1UV5^a	2010 [50]
30	CH	Me	β: 270	β + 2	Yes	1UV5^a	2010 [50]

^aDocking studies, PDB code; β: GSK-3β.