Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of Action
Figure 2
GKW effects in the Morris water maze. Mean ± SEM of (a) escape latency and (b) distance traveled to find platform is shown for each day of testing. Wild-type animals exhibit a “learning curve” requiring less time and less distance to find the hidden platform with repeated trials, while untreated Tg2576 mice require equivalent time and distance despite repeated exposures. In contrast, the GKW-treated mice learn in a manner similar to the wild-type animals, with latency and distance traveled to find the platform declining with repeated exposures. On day 4, time to find the platform was significantly greater for untreated Tg2576 mice than for wild-type () or GKW-treated Tg2576 mice (). Distance traveled to find the platform was also significantly greater on day 4 for untreated Tg2576 mice compared to wild-type () or GKW-treated Tg2576 mice ().
