Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of Action
Figure 4
(a) GKW at 100 and 200 μg/mL shows a modest protective effect on SH-SY5Y cells from Aβ toxicity (beta amyloid 25–35) in vitro. The % of live cells is decreased on treatment with Aβ, an effect which is attenuated by GKW. Hydrogen peroxide 500 μM is used as a 0 cell viability control. (b) GKW at 100 and 200 μg/mL protects SH-SY5Y cells from Aβ toxicity (beta amyloid 25–35) in vitro—LDH release. The amount of LDH (lactate dehydrogenase) released is increased on treatment with Aβ, an effect which is attenuated by GKW. LDH release is a marker of cell damage.
