Alterations in Lipid Levels of Mitochondrial Membranes Induced by Amyloid-ß: A Protective Role of Melatonin
Figure 9
Cholesterol content in mitochondrial membranes is significantly increased in fAβ injected brains. The H2O2 control group (data not shown) and the fAβ experimental group, which showed the more important overproduction of free radicals and the lowest membrane fluidity, coincide with the highest cholesterol content. However, in spite of its ability to scavenge free radicals and restore membrane fluidity, melatonin was unable to reduce cholesterol content in mitochondrial membrane. Compared according to their relative values, cholesterol and total phospholipids ratio was significantly altered.
