493670.fig.005a
(a)
493670.fig.005b
(b)
Figure 5: 2 hours of OGD caused an increase in p-tau202 levels, prevented by either NAP or QVD-OPH treatment. Cultures were treated with M NAP or with 20 μM QVD-OPH (broad spectrum caspase inhibitor, indicated as ) and exposed to OGD insult for 2 hours. Proteins were extracted and analyzed using immunoblot with a specific anti-p-tau202 and antitotal tau antibodies. A representative blot of p-tau202 and total tau is exhibited in (a). P-tau levels were quantified and normalized to total tau levels (ANOVA with post hoc LSD, ) (b).