Review Article
A Changing Perspective on the Role of Neuroinflammation in Alzheimer's Disease
Table 1
Summary of some transgenic mouse studies that have modulated inflammation and the effects these modulations had on the pathology.
| Mode of inflammatory modulation | Genetic model of AD | Pathological changes observed | References | Amyloid load | Tau pathology | Neuronal degeneration | Microglial “activation” |
| LPS intracranial | APP/PS1 amyloid | | | | | [5, 7] | LPS intracranial | rTg4510 tau | | | | | [8] | Anti-Aβ immunotherapy | APP amyloid | | | | | [13, 14] | Anti-Aβ immunotherapy | APP/NOS−/− amyloid, tau, neuron loss | | | | | [17] | IL-1β overexpression in brain | APP/PS1 amyloid | | | | | [22] | TGFβ overexpression in brain | APP amyloid | | | | | [19] | TNFR1 and R2 deletion | 3Xtg amyloid and tau | | | | | [21] |
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