Florbetaben PET in the Early Diagnosis of Alzheimer's Disease: A Discrete Event Simulation to Explore Its Potential Value and Key Data Gaps

Table 3

Model parameters for treatments.

Parameter	Dementia		Predementia		Data source
	Usual care	Florbetaben	Usual care	Florbetaben
% of patients receiving dementia medication at diagnosis	N/A	N/A	28%	N/A	VA VISN 1 and user specification
If Dx = AD+	77%	100%	N/A	100%
If Dx = non-AD	67%	0%	N/A	0%
Distribution of dementia medication	Dx  =  AD+	Dx  =  Non-AD			VA VISN 1
Donepezil	63%	66%	76%
Galantamine	25%	9%	6%
Rivastigmine	5%	4%	1%
Memantine	7%	21%	17%
Maximum dementia treatment duration allowed, years	Life time		5		User specification
Stopping dementia medication if MMSE score is below 10	Yes		N/A		User specification

AD: Alzheimer’s disease; Dx: dementia diagnosis; MMSE: mini-mental state examination; N/A: not applicable.