Reliable Measurements of the β-Amyloid Pool in Blood Could Help in the Early Diagnosis of AD

Table 2

Levels of direct and calculated markers in each group of participants.

Marker	HC				MCI				AD
Direct	𝑛	Mean	CV	Range	𝑛	Mean	CV	Range	𝑛	Mean	CV	Range
UP Aβ1-40	16	15.4^M	47.4	2.2–33.3	7	44.7^H	102.7	14.4–133.6	15	32.2	152.5	7.2–203.2
DP Aβ1-40	16	56.4^M	36.2	21.4–104.3	7	124.6^H	86.9	54.5–339.6	15	115.4	137.3	12.0–645.7
CB Aβ1-40	16	59.3^M∗	28.8	14.5–89.2	7	107.4^H∗	54.7	63.7–211.2	15	103.3	88.2	15.3–328.6
UP Aβ1-42	16	8.0^M∗	38.7	3.7–16.9	7	24.8^H∗	96.8	8.6–67.4	15	23.3	206.0	4.5–195.3
DP Aβ1-42	16	40.1^M	32.2	20.5–78.6	7	75.2^H	66.5	34.9–151.5	15	96.5	183.3	22.3–728.5
CB Aβ1-42	16	58.7^A	23.2	28.4–76.8	7	79.8	35.5	62.9–141.9	15	89.8^H	59.0	52.6–262.6
Calculated
UP Aβ-42/Aβ40	16	0.7	85.7	0.1–2.9	7	0.6	16.7	0.5–0.7	15	0.6	50.0	0.3–1.2
DP Aβ-42/Aβ40	16	0.8	25.0	0.3–1.5	7	0.7	14.3	0.4–0.9	15	0.9	55.5	0.4–2.6
CB Aβ-42/Aβ40	16	1.1	63.6	0.4–3.7	7	0.8	25.0	0.4–1.1	15	1.2	66.7	0.4–3.8
T40	16	115.7^M	29.2	35.9–175.4	7	232.0^H	71.7	118.2–550.8	15	218.8	109.8	27.3–946.5
T42	16	98.8^A,M	24.7	59.7–155.5	7	155.0^H	48.3	103.9–293.4	15	186.3^H	122.0	74.9–991.0
T-βAPB	16	214.5^M	22.1	121.8–307.2	7	387.0^H	60.1	222.8–778	15	405.1	113.1	116.6–1937

All values are expressed in pg/mL. H, M, and A mean significant (𝑃<0.05) with regard to HC, MCI and AD respectively. ^*means 𝑃<0.01.