Microglial Amyloid-1-40 Phagocytosis Dysfunction Is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer’s Disease
Figure 5
Immunohistochemical study of microglial accumulation on A plaques in human AD brains. Free-floating human AD brain sections were incubated with the anti-A40 specific antibody (dark blue) and anti-A42 specific antibody (brown) (a, b), anti-A40 specific antibody (dark blue) and anti-HLA-DR antibody (for microglial staining; brown) (c, d), and anti-A42 specific antibody (dark blue) and anti-HLA-DR antibody (for microglial staining; brown). Arrows and arrow heads show marked and poor microglial accumulations, respectively. (b), (d), and (f) show high-magnification views of squared area in (a), (c), and (e), respectively. Scale bar in (a) equals 400 μm for (a), (c), and (e). Scale bar in (b) equals 100 μm for (b), (d), and (f).
