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Figure 5: Immunohistochemical study of microglial accumulation on A plaques in human AD brains. Free-floating human AD brain sections were incubated with the anti-A 40 specific antibody (dark blue) and anti-A 42 specific antibody (brown) (a, b), anti-A 40 specific antibody (dark blue) and anti-HLA-DR antibody (for microglial staining; brown) (c, d), and anti-A 42 specific antibody (dark blue) and anti-HLA-DR antibody (for microglial staining; brown). Arrows and arrow heads show marked and poor microglial accumulations, respectively. (b), (d), and (f) show high-magnification views of squared area in (a), (c), and (e), respectively. Scale bar in (a) equals 400 μm for (a), (c), and (e). Scale bar in (b) equals 100 μm for (b), (d), and (f).