About this Journal Submit a Manuscript Table of Contents
International Journal of Alzheimer’s Disease
Volume 2012 (2012), Article ID 731526, 13 pages
http://dx.doi.org/10.1155/2012/731526
Review Article

Structure and Pathology of Tau Protein in Alzheimer Disease

1Laboratory of Biochemistry and Brain Pathophysiology and AD Center, Prague Psychiatric Center, Ústavní 91, 181 03 Prague 8, Czech Republic
2Third Faculty of Medicine, Charles University in Prague, Ruská 87, 100 00 Prague 10, Czech Republic
3Department of Cell Biology, Center of Research and Advanced Studies, National Polytechnic Institute, Avenue Instituto Politecnico Nacional 2508, 07360 Mexico City, DF, Mexico
4Department of Neurology, Third Faculty of Medicine, Faculty Hospital Královské Vinohrady, Charles University in Prague, Šrobárova 50, 100 34 Prague 10, Czech Republic

Received 19 January 2012; Revised 28 March 2012; Accepted 29 March 2012

Academic Editor: David Blum

Copyright © 2012 Michala Kolarova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [24 citations]

The following is the list of published articles that have cited the current article.

  • Ales Bartos, Lenka Fialova, Jana Svarcova, and Daniela Ripova, “Patients with Alzheimer disease have elevated intrathecal synthesis of antibodies against tau protein and heavy neurofilament,” Journal Of Neuroimmunology, vol. 252, no. 1-2, pp. 100–105, 2012. View at Publisher · View at Google Scholar
  • Sunmin Park, Da Sol Kim, Suna Kang, and Na Rang Moon, “β-Amyloid-induced cognitive dysfunction impairs glucose homeostasis by increasing insulin resistance and decreasing β-cell mass in non-diabetic and diabetic rats,” Metabolism, 2013. View at Publisher · View at Google Scholar
  • Jan Říčný, “Overlooked Alzheimer’s Smoking Gun?,” Neurochemical Research, 2013. View at Publisher · View at Google Scholar
  • Ramasamy Thangavel, Duraisamy Kempuraj, Deirdre Stolmeier, Poojya Anantharam, Mohammad Khan, and Asgar Zaheer, “Glia Maturation Factor Expression in Entorhinal Cortex of Alzheimer’s Disease Brain,” Neurochemical Research, 2013. View at Publisher · View at Google Scholar
  • Yancy Ferrer-Acosta, Eva N. Rodríguez-Cruz, François Orange, Hector De Jesús-Cortés, Bismark Madera, Jaime Vaquer-Alicea, Juan Ballester, Maxime J.-F. Guinel, George S. Bloom, and Irving E. Vega, “EFhd2 is a novel amyloid protein associated with pathological tau in Alzheimer's disease,” Journal of Neurochemistry, vol. 125, no. 6, pp. 921–931, 2013. View at Publisher · View at Google Scholar
  • Wolfgang Froestl, Andrea Pfeifer, and Andreas Muhs, “Cognitive Enhancers (Nootropics). Part 3: Drugs Interacting with Targets other than Receptors or Enzymes. Disease-modifying Drugs,” Journal Of Alzheimers Disease, vol. 34, no. 1, pp. 1–114, 2013. View at Publisher · View at Google Scholar
  • Khushwant S. Bhullar, and H. P. Vasantha Rupasinghe, “Polyphenols: Multipotent Therapeutic Agents in Neurodegenerative Diseases,” Oxidative Medicine and Cellular Longevity, vol. 2013, pp. 1–18, 2013. View at Publisher · View at Google Scholar
  • Bruno Bulic, Marcus Pickhardt, and Eckhard Mandelkow, “Progress and Developments in Tau Aggregation Inhibitors for Alzheimer Disease,” Journal Of Medicinal Chemistry, vol. 56, no. 11, pp. 4135–4155, 2013. View at Publisher · View at Google Scholar
  • Shraddha D. Rege, Thangiah Geetha, Gerald D. Griffin, Tom L. Broderick, and Jeganathan Ramesh Babu, “Neuroprotective effects of resveratrol in Alzheimer disease pathology,” Frontiers in Aging Neuroscience, vol. 6, 2014. View at Publisher · View at Google Scholar
  • Julia E. Gerson, Diana L. Castillo-Carranza, and Rakez Kayed, “Advances in Therapeutics for Neurodegenerative Tauopathies: Moving toward the Specific Targeting of the Most Toxic Tau Species,” ACS Chemical Neuroscience, pp. 140808101712009, 2014. View at Publisher · View at Google Scholar
  • P. Cermakova, M. Eriksdotter, L. H. Lund, B. Winblad, P. Religa, and D. Religa, “Heart failure and Alzheimer′s disease,” Journal of Internal Medicine, 2014. View at Publisher · View at Google Scholar
  • Tamás Vajda, and András Perczel, “Role of water in protein folding, oligomerization, amyloidosis and miniprotein,” Journal of Peptide Science, 2014. View at Publisher · View at Google Scholar
  • Fouad H. Darras, Sarah Wehle, Guozheng Huang, Christoph A. Sotriffer, and Michael Decker, “Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with “inverted” binding mode,” Bioorganic & Medicinal Chemistry, 2014. View at Publisher · View at Google Scholar
  • Dante J. Marciani, “New Th2 adjuvants for preventive and active immunotherapy of neurodegenerative proteinopathies,” Drug Discovery Today, vol. 19, no. 7, pp. 912–920, 2014. View at Publisher · View at Google Scholar
  • Min Xie, Shao-Hui Wang, Zhi-Min Lu, Ying Pan, and Qi-Cai Chen, “UCH-L1 Inhibition Involved in CREB Dephosphorylation in Hippocampal Slices,” Journal of Molecular Neuroscience, vol. 53, no. 1, pp. 59–68, 2014. View at Publisher · View at Google Scholar
  • Chiara Appocher, Raffaella Klima, and Fabian Feiguin, “Functional screening in Drosophila reveals the conserved role of REEP1 in promoting stress resistance and preventing the formation of Tau aggregates,” Human Molecular Genetics, vol. 23, no. 25, pp. 6762–6772, 2014. View at Publisher · View at Google Scholar
  • Sungsu Lim, Md. Mamunul Haque, Dohee Kim, Dong Jin Kim, and Yun Kyung Kim, “Cell-based models to investigate tau aggregation,” Computational and Structural Biotechnology Journal, 2014. View at Publisher · View at Google Scholar
  • Xin Zhou, Chun Yang, Yufeng Liu, Peng Li, Huiying Yang, Jingxing Dai, Rongmei Qu, and Lin Yuan, “Lipid rafts participate in aberrant degradative autophagic-lysosomal pathway of amyloid-beta peptide in Alzheimer's disease,” Neural Regeneration Research, vol. 9, no. 1, pp. 92–100, 2014. View at Publisher · View at Google Scholar
  • Jan Torleif Pedersen, and Einar M. Sigurdsson, “Tau immunotherapy for Alzheimer's disease,” Trends In Molecular Medicine, vol. 21, no. 6, pp. 394–402, 2015. View at Publisher · View at Google Scholar
  • Oliver Reimann, Maria Glanz, and Christian P. R. Hackenberger, “Native chemical ligation between asparagine and valine: Application and limitations for the synthesis of tri-phosphorylated C-terminal tau,” Bioorganic & Medicinal Chemistry, vol. 23, no. 12, pp. 2890–2894, 2015. View at Publisher · View at Google Scholar
  • Dong-Young Choi, and Hyukjae Choi, “Natural products from marine organisms with neuroprotective activity in the experimental models of Alzheimer's disease, Parkinson's disease and ischem,” Archives Of Pharmacal Research, vol. 38, no. 2, pp. 139–170, 2015. View at Publisher · View at Google Scholar
  • Yu Jin, Takeshi Kanno, and Tomoyuki Nishizaki, “Acute Restraint Stress Impairs Induction of Long-Term Potentiation by Activating GSK-3 beta,” Neurochemical Research, vol. 40, no. 1, pp. 36–40, 2015. View at Publisher · View at Google Scholar
  • Zhenzhen Liu, Tao Li, Ping Li, Nannan Wei, Zhiquan Zhao, Huimin Liang, Xinying Ji, Wenwu Chen, Mengzhou Xue, and Jianshe Wei, “The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer’s Disease,” Oxidative Medicine and Cellular Longevity, vol. 2015, pp. 1–12, 2015. View at Publisher · View at Google Scholar
  • Andrea Spolcova, Barbora Mikulaskova, Martina Holubova, Veronika Nagelova, Zdenko Pirnik, Jana Zemenova, Martin Haluzik, Blanka Zelezna, Marie-Christine Galas, and Lenka Maletinska, “Anorexigenic Lipopeptides Ameliorate Central Insulin Signaling and Attenuate Tau Phosphorylation in Hippocampi of Mice with Monosodium Glutamate-Induc,” Journal Of Alzheimers Disease, vol. 45, no. 3, pp. 823–835, 2015. View at Publisher · View at Google Scholar