The Biphasic Role of Microglia in Alzheimer's Disease

Figure 2

Inflammatory molecules produced by Aβ- or LPS-activated microglia. In primary microglial culture, administration of 5 μM oAβ42 or 5 μM fAβ42 for 24 h does not induce the production of neurotoxic mediators such as TNF-α, glutamate, or nitrite, a stable breakdown product of NO. While microglia activated with 1 μg/mL LPS produce these molecules, both oAβ42 and fAβ42 do not enhance the production.