Silencing of Amyloid Precursor Protein Expression Using a New Engineered Delta Ribozyme

Figure 1

Secondary structure of both the Off and On conformations of the SOFA-HDV ribozyme. The original HDV ribozymes in the grey shaded boxes with its recognition domain (in blue) indicated. The SOFA is composed of three motifs : the biosensor (in green), blocker (in red), and stabilizer stem. Upon the addition of APP mRNA, sequence-specific hybridization to the ribozyme occurs, and the substrate is subsequently cleaved.