Silencing of Amyloid Precursor Protein Expression Using a New Engineered Delta Ribozyme

Figure 6

Effect of the most active ribozyme on the level of secreted total amyloid. The secreted levels of A𝛽_1-x were detected by sandwich ELISA, as described in Section 2. Media were collected following SH-SY5Y infection with the Rz-APP-286, Rz-APP-753, or pRNAT empty vector. The results are presented as the means ± SEM from 3 independent experiments. **𝑃<0.001. Control cells were infected with the empty pRNAT vector.