A Unifying Hypothesis for Familial and Sporadic Alzheimer's Disease
Figure 5
Increased Aβ clearance on day 8 with additional interventions. Each graph shows the mean of 100 simulations. (a) Blockage of ROS production via Aβ (parameter for Aβ-mediated ROS production set to zero). (b) Inhibition of GSK3β/p53 binding (parameter for GSK3β/p53 binding set to zero). Note that apart from p53, all proteins shown in the graphs have levels close to zero and so not all the lines can be seen.
