A Unifying Hypothesis for Familial and Sporadic Alzheimer's Disease
Figure 7
New hypotheses of AD involving GSK3 and p53. Our model supports that the pathway between Aβ and tau is via ROS, p53, and GSK3β. Note that there is a cycle in the diagram between GSK3β, Aβ, ROS, and p53 which can start at any point. Full details are in the text.
