Role of Copper and Cholesterol Association in the Neurodegenerative Process

Table 4

A𝛽 (1–40 and 1–42) peptide concentrations and the ratio A𝛽 (1–42)/(1–40) in plasma and in brain regions (cortex and hippocampus) in rats fed with the experimental diets.

Treatments		Plasma		Brain zones
				Cortex			Hippocampus
	A𝛽 (1–40)	A𝛽 (1–42)	A𝛽 (1–42)/(1–40)⋅10^2	A𝛽 (1–40)	A𝛽 (1–42)	A𝛽 (1–42)/(1–40)⋅10^2	A𝛽 (1–40)	A𝛽 (1–42)	A𝛽 (1–42)/(1–40)⋅10^2
C	82.65±1.91^a	7.06±0.15^a	8.55±0.15^a	59.49±1.91^a	8.15±0.33^a	7.30±0.16^a	31.56±1.85^a	5.01±0.26^a	6.30±0.12^a
Cu	94.62±1.55^b	8.44±0.31^b	8.92±0.23^a	88.87±1.44^b	9.66±0.45^a	9.20±0.22^b	41.18±1.81^b	6.24±0.20^a	6.60±0.24^a
Cho	112.05±2.33^c	9.95±0.33^c	8.88±0.33^a	115.58±1.29^c	12.04±0.28^b	9.60 ± 0.18^b	72.65±2.22^c	7.49±0.18^b	9.70±0.15^b
CuCho	132.76±2.40^d	12.56±0.22^d	9.46±0.28^a	176.40±2.03^d	15.74±0.25^c	11.20 ± 0.26^c	87.76±1.44^d	8.82±0.21^c	9.97±0.22^b

Results (mean of 10 animals assayed in triplicate ± SD) were obtained as described in Section 2.12.1. Individual peptides are expressed as picomoles/L (plasma) or picomoles/mg protein (brain homogenates). Results statistically significantly different (𝑃<0.01) are indicated with distinct superscript letters (values within the same column with different superscript letters are statistically significant between them).